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Immunogenetics & Transplantation Lab »  Diagnostic Services

Diagnostic Services

The ITL performs histocompatibility testing for therapeutic transplantation including hematopoietic stem cell transplantation from related and unrelated donors and solid organ transplantations including kidney, pancreas, liver, heart, lung, intestine, and vascularized composite organs. The ITL also performs testing for transfusion services, HLA-associated diseases, drug-induced hypersensitivity, vaccine trials, and cellular therapies. 

Diagnostic testing and services include:

HLA Typing

  • High resolution HLA typing
  • Intermediate resolution HLA typing

HLA Antibody Testing

  • Antibody identification
  • Panel reactive antibody (PRA)

Crossmatch Testing

  • Flow cytometer crossmatch (FCXM)
  • Virtual Crossmatch (VXM)
  • Endothelial cell crossmatch to detect non-HLA antibodies (EXM)

Chimerism Testing and Engraftment Monitoring

  • Chimerism testing is performed by analyzing short tandem repeats (STR) using an in-house developed and optimized test.

KIR Genotyping

  • To select stem cell donors to improve leukemia control after hematopoietic stem cell transplantation
  • To determine disease association

Disease Association and Drug Hypersensitivity

  • Tested at the optimum resolution.
  • Test comments that are relevant to clinical management are included in the report.
  • Consultation is available for test selection and interpretation of results.

HLA Laboratory Service to Solid Organ Transplant Programs

  • State-of-the-art testing.
  • Fast turn-around-time.
  • Wide array of tests, from pre-transplant to post-transplant monitoring. Virtual crossmatch available 24/7.

HLA Laboratory Service to Hematopoietic Stem Cell Transplant Programs

  • Tests agreement is created to meet the transplant program’s requirements, and reviewed as needed.
  • ITL Laboratory Information System (LIS) can be integrated with program’s Electronic Health Record (EHR) system for real-time reporting of results.
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