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Immunogenetics & Transplantation Lab »  Diagnostic Services »  Disease Association and Drug Hypersensitivity

Disease Association and Drug Hypersensitivity

Tests

  • HLA-B27 is associated with a group of autoimmune diseases termed seronegative spondyloarthropathies, which included ankylosing spondylitis, psoriatic arthritis, and reactive arthritis (formerly termed Reiter syndrome). 
  • HLA-A29 is associated with Birdshot Retinochoroidopathy
  • HLA-B51 is associated with Behcet’s disease, a rare chronic inflammatory multisystem disorder. 
  • HLA-B*15:02 is strongly associated with hypersensitivity to carbamazepine, an anti-epileptic medication.
  • HLA-B*57:01 is strongly associated with hypersensitivity to abacavir, a retroviral medication.
  • HLA-B*58:01 is strongly associated with hypersensitivity to allopurinol, a medication used for hyperuricemia-related diseases such as gout and recurrent urate kidney stones.
  • HLA-DQ2 and HLA-DQ8 are associated with risk of Celiac disease.

Highlights  

  • Tested at the optimum resolution.
  • Test comments that are relevant to clinical management are included in the report.
  • Consultation is available for test selection and interpretation of results.

Turn-Around-Time

  (assuming samples received before 10:00 am)

  • Routine testing reported in 4-10 business days
  • STAT testing reported in ≤ 3 business days
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