University of California San Francisco

Immunogenetics and Transplantation Laboratory (ITL) - Homepage

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Rajalingam Raja, PhD, F(ACHI), FRCP

Clinical Professor of Surgery 
Director, Immunogenetics and Transplantation Laboratory

 

Diagnostic Testing, Research & Education

The UCSF Immunogenetics and Transplantation Laboratory (ITL) is a CLIA-certified, ASHI-accredited, CMS-approved freestanding histocompatibility laboratory licensed by both California and New York. Housed in a newly constructed, custom designed, state-of-the-art facility with approximately 10,000 square feet of laboratory space dedicated to histocompatibility and immunogenetics testing, ITL has state-of-the-art equipment and liquid handling systems to support quality high volume testing. 

ITL provides diagnostic HLA testing services for therapeutic transplantation, disease associations, drug hypersensitivity, and transfusion services. ITL facilitates over 800 organ (kidney, liver, lung, heart, pancreas, and islet) and hematopoietic stem cell transplantations per year at UCSF. ITL serves as a contract laboratory for Donor Network West, the northern California organ procurement organization. As a freestanding HLA laboratory, the ITL provides services to non-UCSF clients including transplant programs in other states. 

ITL is also a core HLA laboratory for the Immune Tolerance Network, a research cooperative focused on the development of therapeutic approaches for asthma and allergy, autoimmune diseases, and organ transplantation that lead to immune tolerance. ITL performs testing for clinical trials, and conducts basic and translational research in immunology, immunogenetics, molecular biology, and transplant immunology.  

In addition, ITL provides educational programs in immunogenetics and transplant immunology for healthcare professionals. 

Licenses and Certificates 

The Immunogenetics and Transplantation Laboratory provides quality diagnostic testing, research, and education as vital contributions to optimal patient care and leadership in the advancement of our discipline.
Rajalingam Raja Director, Immunogenetics & Transplantation Lab

Collaborations

Our Research

  1. Define the functional histocompatibility to increase the number of transplants and improve transplant outcomes by identifying acceptable HLA mismatches and tolerable donor-specific HLA antibodies (DSA)...
  2. Understand the function of germline-encoded polymorphism of immunity related genes (HLA, KIR, KLR, and FcR) in human populations and their impact on infections, tumor transformation, autoimmune diseases, pregnancy success and allogeneic solid organ and bone marrow transplantation....
  3. Genes encoding killer-cell Immunoglobulin-like receptors (KIR) and HLA class I ligands are located on different chromosomes, and both feature extraordinary diversity in the number and type of genes...

Read Full Research

Support the Lab

Your generous support of the Immunogenetics and Transplantation Laboratory helps scientists discover new treatments for bone marrow, cornea transplantation and more.